Insulin glargine amide was found to show a time/effect profile which is distinctly more flat and thus more advantageous than insulin glargine itself.
The aim of the study was to obtain recombinant PAM and use it for insulin analogue amidation.
Accordingly, there are thousands of studies on ANP release and action, in both animal and man.
In contrast to this wealth of knowledge, the cell biology of ANP-containing secretory vesicles is far less understood.
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ANP and brain natriuretic peptide have become important clinical markers of cardiac hypertrophy and failure.
Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides.
of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced. This subsection of the ‘Subcellular location’ section describes the extent of a membrane-spanning region of the protein.
It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins. / Processing section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation.
ANP (atrial natriuretic peptide) is widely recognized as an important vasorelaxant, diuretic, and cardioprotective hormone.
Little is known, however, about how ANP-secretory vesicles form within the atrial myocytes.